Novel DOX-MTX NPs Affect Her-2 Expression and Improve Outcome in an OSCC Rat Model in Vivo

Oral squamous cells carcinomas (OSCCs) accounts for approximately 95% of all oral malignant neoplasms and for about 38% of all malignant head and neck tumors, especially the tongue and lip (Jones et al., 1992; Brandwein-Gensler et al., 2005; Bell et al., 2007). Unfortunately, the increase in incidence has not been paralleled by the development of new therapeutic agents and the 5-year survival rate remains at 50% over the past 30 years(Mesgari Abbasi et al., 2014c). Among oral neoplasm, tongue carcinoma exhibit a late diagnosis and a more aggressive form and unfortunately an unfavorable prognosis , the vast majority of Stages III and IV cases are fatal (Schliephake, 2003; Massano et al., 2006; Montoro et al., 2008). The epidermal growth factor receptor (EGFR)-related